Major International PURE Study Reveals Major Risk Factor: A high carbohydrate diet is associated with increased all-cause mortality. Posted on November 9, 2017 | by Functional Developer | Leave a Comment on Major International PURE Study Reveals Major Risk Factor: A high carbohydrate diet is associated with increased all-cause mortality. With what is possibly the largest macronutrient-disease association study ever conducted, researchers discovered that the more dietary fat populations consumed, the better. Over 135,000 participants from 18 different countries on 5 different continents were followed for 10 years. This prospective follow-up study investigated how carbohydrate, fat, and protein levels influenced all cause mortality as well as risk for a variety of cardiovascular diseases. Continue reading →