Gastroparesis is a syndrome that results from delayed emptying of the stomach in the absence of a mechanical obstruction. It can be a very challenging problem with typical symptoms of nausea (93%), early satiety (60-86%), vomiting after meals (68—84%), bloating, and with upper abdominal pain (46-90%). The overall prevalence of gastroparesis is 9.6 per 100,000 men and 38 per 100,000 women. Motility of the stomach and gastrointestinal tract requires coordination of the nervous system, smooth muscles of the gut and specialized “pacemaker cells” known as interstitial cells of Cajal. These pacemaker cells play an important role of the synchronization of contractions of the stomach. Continue reading